Treatments / Rx (info only)
Low-dose naltrexone
2050
Grade None
Info only
Evidence estimate
51%
See what people report
80% interval 30 to 72% · effective n 6.8
Overview
Prescription information only. Some clinicians use LDN off-label for post-viral symptoms.
Mechanisms it may act on
- Immune / post-viral Plausible
Where the estimate comes from
- From studies (prior): 2.0
- From Reddit reports: 4.8
- From investigators here: 0.0
- From tests: 0.0
Studies
-
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).2026 · European journal of pain (London, England) · n=48 · Null · PubMed 42385209
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Effect of low-dose naltrexone for long COVID: a systematic review and meta-analysis.2026 · BMJ open · n=155 · Positive · PubMed 42463201
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TREATME survey of treatments for long COVID and ME/CFS2025 · PNAS · n=951 · Positive · PubMed TREATME-PNAS-2025
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Low Dose Naltrexone in the Treatment of Fibromyalgia.2018 · Current rheumatology reviews · n=? · · PubMed 28325149
Reddit reports
Coded from public Reddit posts. People who post tend to have strong results either way.
- Helped: 9
- Partly: 9
- No change: 6
- Worse: 0
How people usually try it
Talk to your doctor. DIY Health never tells you to start, stop, or change a prescription.
Typical dose: Clinician-directed
Safety
Prescription. Talk to your doctor.
Prescription. Talk to your doctor.
Not medical advice, not a diagnosis, and not a substitute for a clinician.